Image: N. Watson, L. Thompson, MITGenomes of individual organisms and systems of organisms contain the information and operating capabilities that determine structure and function across multiple scales of biological organization. These complex systems hold the secrets of life. Because we do not yet have a full understanding of how a living system works, and how these organisms interact with and modify their environments, the Department of Energy’s (DOE) Genomic Science Program is working to achieve a predictive, system-level understanding of plants, microbes, and biological communities. This program is providing the foundational knowledge underlying biological approaches to producing biofuels, sequestering carbon in terrestrial ecosystems, and cleaning up contaminated environments.